Fig 3.

COX isozyme expression, PG levels, and skin morphology in age-matched transgenic as compared with wt mice. (a) COX isozyme expression in epidermis from wt mice and the transgenic lines K5.COX-2/19^+/− (19) and K5.COX-2/667^+/− (667). (b) Epidermal PG levels (mean ± SEM; PGE₂, black bars; PGF_2α, white bars; 6-keto-PGF_1α, gray bars) in wt mice (n = 5) and the transgenic mice K5.COX-2/19^+/− (19, n = 5) and K5.COX-2/667^+/− (667, n = 3); P values for PGE₂ and PGF_2α (wt vs. K5.COX-2/667^+/−) were ≤0.036. Epidermal histology and localization of Ki67-positive keratinocytes are shown for skin sections from wt mice (c) and the transgenic mice of K5.COX-2/19^+/− (d) and K5.COX-2/667^+/− (e). [Magnification: ×400.]