Developmental changes in levels of LeGCHI mRNA, LeGCHI protein, and
folate in tomato fruits. (A) Northern analysis of LeGCHI
mRNA. Lanes contained 10 μg of total RNA from fruits at mature green
(MG), breaker (Br), ripe (R), and red-ripe (RR) stages or from young
leaves. Blots were probed with the LeGCHI coding sequence
(Upper) and then with an 18S ribosomal DNA sequence
(Lower) as a loading control. The sizes (kb) of the
hybridizing RNAs are indicated. (B) Western analysis of
LeGCHI protein in fruits. Lanes contained 20 μg of protein; the
positions of molecular mass markers (kDa) are shown. The
Upper blot was probed with anti-GCHI serum and the
Lower blot with control antiserum depleted in anti-GCHI
antibodies by preincubation with purified recombinant LeGCHI.
(C) 5-Methyltetrahydrofolate (methyl-THF) levels in
fruits. The data are means of three replicates ± SE. FW, fresh
weight.