Table 2.
Outcomes comparison.
| Unweighted cohort | Weighted cohort | ||||||
|---|---|---|---|---|---|---|---|
| Cancer (n = 247) | No cancer (n = 1,402) | Cancer (n = 759) | No cancer (n = 890) | Statistical metric a | Weighted difference [95% CI] | P value | |
| Primary outcome | |||||||
| 90-day new ischaemic stroke or TIA, n (%) | 20 (8.1) | 37 (2.6) | 62 (8.2) | 25 (2.8) | Adjusted hazard ratio | 2.56 [1.59–4.13] | <.001 |
| Secondary outcomes | |||||||
| 90-day mRS score distribution | Adjusted odds ratio | 1.29 [1.08–1.54] | .005 | ||||
| No symptoms (score of 0), n (%) | 13 (5.3) | 172 (12.3) | 84 (11.1) | 112 (12.6) | |||
| Symptoms without any disability (score of 1), n (%) | 33 (13.4) | 251 (17.9) | 85 (11.2) | 163 (18.3) | |||
| Symptoms with mild disability (score of 2), n (%) | 36 (14.6) | 205 (14.6) | 128 (16.9) | 150 (16.9) | |||
| Symptoms with mild-to-moderate disability (score of 3), n (%) | 48 (19.4) | 221 (15.8) | 145 (19.1) | 140 (15.7) | |||
| Symptoms with moderate-to-severe disability (score of 4), n (%) | 42 (17.0) | 178 (12.7) | 121 (15.9) | 110 (12.4) | |||
| Symptoms with severe disability (score of 5), n (%) | 19 (7.7) | 97 (6.9) | 60 (7.9) | 57 (6.4) | |||
| Death (score of 6), n (%) | 56 (22.7) | 278 (19.8) | 136 (17.9) | 158 (17.8) | |||
| 90-day all-cause death, n (%) | 56 (22.7) | 278 (19.8) | 136 (17.9) | 158 (17.8) | Adjusted hazard ratio | 0.98 [0.78–1.24] | .883 |
| 90-day vascular death, n (%) | 31 (12.6) | 184 (13.1) | 82 (10.8) | 101 (11.3) | Adjusted hazard ratio | 0.94 [0.70–1.26] | .677 |
| Safety outcomes | |||||||
| 90-day moderate-to-severe bleeding, n (%) | 16 (6.5) | 39 (2.8) | 33 (4.3) | 21 (2.4) | Adjusted hazard ratio | 1.82 [1.05–3.14] | .033 |
| 90-day ICH, n (%) | 7 (2.8) | 22 (1.6) | 16 (2.1) | 11 (1.2) | Adjusted hazard ratio | 1.66 [0.77–3.58] | .194 |
| 24-h haemorrhagic transformation, n (%) | 35 (14.2) | 252 (18.0) | 125 (16.5) | 158 (17.8) | Adjusted risk difference (%) | 0.2 [−3.8 to 4.2] | .931 |
Global Schoenfeld residual P-values: 90-day new ischaemic stroke or TIA = 0.422; 90-day vascular death = 0.550; 90-day all-cause death = 0.861; 90-day moderate-to-severe bleeding = 0.663; 90-day ICH = 0.224. Statistically significant P-values (<0.05) are reported in bold.
aAdjusted for baseline covariates that remained imbalanced (SMD > 0.10) after weighting (age, ethnicity, pre-stroke mRS, atrial fibrillation type, post-stroke anticoagulation strategy).