Table 1.

Effects of oral gavage of JBD0131 on open field observation parameters in SD rats

Parameter	Time point	Control group		Vehicle Group		50 mg/kg Group		150 mg/kg Group		500 mg/kg Group
		n	Mean ± SD	n	Mean ± SD	n	Mean ± SD	n	Mean ± SD	n	Mean ± SD
Fecal pellet count	Before administration (0 h)	10	1.5 ± 1.8	10	2.0 ± 1.6	10	2.4 ± 2.3	10	2.5 ± 2.4	10	3.1 ± 1.5
	8 h after administration	10	2.2 ± 1.9	10	2.7 ± 2.1	10	2.8 ± 3.2	10	1.6 ± 1.7	10	2.8 ± 2.1
	24 h after administration	10	2.9 ± 2.0	10	3.5 ± 1.8	10	2.1 ± 2.6	10	3.4 ± 2.5	10	3.3 ± 0.9
	48 h after administration	10	1.8 ± 1.3	10	2.8 ± 2.0	10	2.5 ± 1.6	10	2.6 ± 2.1	10	2.9 ± 2.4
Number of urinations	Before administration (0 h)	10	0.0 ± 0.0	10	0.8 ± 0.6 *	10	0.2 ± 0.4	10	0.9 ± 0.3 *	10	0.6 ± 0.5 *
	8 h after administration	10	0.8 ± 0.6 ▲	10	0.4 ± 0.7	10	0.4 ± 0.5	10	0.9 ± 0.3	10	0.3 ± 0.5
	24 h after administration	10	0.0 ± 0.0	10	1.2 ± 0.8 *	10	0.5 ± 0.5	10	0.9 ± 0.6 *	10	1.1 ± 0.6 *
	48 h after administration	10	0.4 ± 0.5 ▲	10	0.0 ± 0.0 ▲	10	0.9 ± 0.9	10	0.8 ± 0.4	10	0.2 ± 0.4
Number of rearing	Before administration (0 h)	10	6 ± 1	10	12 ± 4 *	10	10 ± 2	10	9 ± 4	10	9 ± 3
	8 h after administration	10	13 ± 2 ▲	10	10 ± 3	10	16 ± 5 ▲	10	12 ± 4	10	11 ± 4 ▲
	24 h after administration	10	7 ± 1	10	15 ± 3 ▲*	10	11 ± 5 *	10	7 ± 4	10	12 ± 2 ▲*
	48 h after administration	10	7 ± 2	10	9 ± 1 ▲	10	10 ± 2 *	10	7 ± 4	10	11 ± 3 *

^*Compared with the control group, the difference between group means is statistically significant (P ≤ 0.05)

▲ Compared with the pre-administration time point, the difference in means is statistically significant (P ≤ 0.05)