Table 3.

Mean toxicokinetic parameters of JBD0131 and DM131 in SD rat plasma following oral gavage of JBD0131

Test compound	Days of administration	Sex	Dose (mg/kg)	n	AUClast (h*ng/mL)		Cmax (ng/mL)
					Mean	SD	Mean	SD
JBD0131	1	Female	30	5	3000	721	251	17.4
			120	5	7890	2130	522	83.9
			480	5	26,300	20,600	802	104
		Male	30	5	3650	255	239	16.1
			120	5	8280	4550	425	18.4
			480	5	18,700	12,100	643	95.4
	28	Female	30	5	3490	440	223	11.5
			120	5	4860	307	358	44.1
			480	5	8680	1600	448	66.3
		Male	30	5	2390	130	174	17.8
			120	5	3640	442	227	20
			480	5	7930	2070	343	32.2
DM131	1	Female	30	5	1210	274	87.6	11.7
			120	5	1050	358	54.5	12.2
			480	5	4960	4260	109	40.1
		Male	30	5	1410	110	90.7	5.8
			120	5	1970	1180	84.4	11.8
			480	5	3130	2480	97.7	30.3
	28	Female	30	5	882	179	50.6	4.71
			120	5	1650	291	94	13.6
			480	5	2230	609	82.1	12.7
		Male	30	5	643	135	40.4	5.64
			120	5	1310	136	57.5	3.24
			480	5	2700	973	88	18.7

AUC_lastarea under the plasma concentration–time curve from time zero to the last measurable concentration

C_maxmaximum plasma concentration