Table 3. DALY trends for cancers by type, gender and province (1990–2019).
| DALYs | 1990 | 2000 | 2010 | 2019 | AAPC between 1990 and 2019 (95% CI) |
||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (95% UI) |
ASR/100,000 (95% UI) |
Cases (95% UI) |
ASR/100,000 (95% UI) |
Cases (95% UI) |
ASR/100,000 (95% UI) |
Cases (95% UI) |
ASR/100,000 (95% UI) |
||
| Cancer subtype | |||||||||
| Acute lymphoid leukemia | 52,913 (29,445–107,459) |
33.56 (20.26–63.32) |
79,057 (50,412–137,802) |
40.95 (27.61–67.32) |
105,241 (74,371–154,819) |
43.01 (31.21–61.67) |
127,533 (93,911–175,502) |
45.07 (33.56–61.62) |
3.15 (2.94–3.33) |
| Acute myeloid leukemia | 34,235 (24,347–52,244) |
29.19 (22.9–38.58) |
50,750 (35,333–72,268) |
34.76 (26.72–44.72) |
69,420 (50,571–89,775) |
37.34 (28.99–46.69) |
90,151 (67,285–116,288) |
40.05 (31.26–50.17) |
3.43 (3.34–3.52) |
| Bladder cancer | 61,139 (49,708–73,023) |
109.48 (88.37–131.19) |
82,347 (70,817–95,039) |
127.51 (109.57–147.61) |
107,072 (86,734–129,235) |
131.55 (107–157.67) |
139,936 (110,285–178,027) |
129.29 (102.16–164.53) |
2.9 (2.88–2.92) |
| Brain and central nervous system cancer | 107,535 (69,104–170,537) |
86.05 (62.68–124.58) |
146,689 (96,828–210,688) |
99.27 (70.43–132.65) |
191,150 (127,521–246,505) |
101.25 (71.11–127.47) |
237,760 (161,752–309,213) |
105.47 (72.77–137.31) |
2.84 (2.75–2.93) |
| Breast cancer | 325,816 (239,525–433,840) |
492.19 (360.72–660.87) |
558,810 (463,595–666,625) |
680.4 (559.98–824.85) |
788,356 (617,517–985,305) |
733.76 (578.57–905.46) |
1,119,378 (847,412–1,520,925) |
783.3 (597.3–1,054.53) |
4.38 (4.35–4.42) |
| Cervical cancer | 48,396 (39,053–60,790) |
70.9 (57.13–89.6) |
77,330 (59,093–94,344) |
89.66 (69.01–109.04) |
91,182 (67,918–119,158) |
79.68 (60.12–102.99) |
110,786 (78,203–158,090) |
73.05 (52.23–102.66) |
2.91 (2.88–2.94) |
| Chronic lymphoid leukemia | 10,556 (8,653–13,072) |
17.64 (14.49–21.87) |
16,097 (13,462–19,232) |
22.65 (18.95–27) |
21,023 (16,909–25,926) |
23.16 (18.86–28.58) |
27,827 (21,960–35,968) |
22.99 (18.43–29.18) |
3.4 (3.38–3.43) |
| Chronic myeloid leukemia | 41,818 (20,055–86,132) |
36.54 (24.01–58.51) |
49,378 (29,551–84,465) |
37.75 (26.9–53.47) |
51,387 (33,405–78,919) |
31.92 (22.65–43.72) |
54,960 (40,157–76,659) |
27.79 (21.05–36.46) |
0.99 (0.9–1.07) |
| Colon and rectum cancer | 77,682 (66,197–89,591) |
127.68 (109.09–147.26) |
133,571 (116,797–151,591) |
181.75 (158.91–205.35) |
181,777 (150,972–216,924) |
192.06 (160.07–227.44) |
249,316 (199,384–312,981) |
198.31 (159.17–248.72) |
4.11 (4.09–4.14) |
| Esophageal cancer | 112,246 (95,366–131,766) |
185.61 (157.4–216.94) |
167,010 (141,944–188,794) |
229.15 (193.3–258.95) |
208,464 (170,019–248,539) |
221.22 (181.92–263.45) |
260,192 (204,466–323,900) |
207.08 (165.9–255.39) |
2.97 (2.94–3.02) |
| Gallbladder and biliary tract cancer | 40,914 (33,942–52,082) |
68.96 (56.57–88.1) |
66,236 (54,532–77,235) |
93.4 (77.11–109.51) |
79,863 (64,511–95,782) |
88.26 (71.58–105.73) |
100,554 (78,212–127,934) |
83.66 (65.6–104.73) |
3.15 (3.12–3.18) |
| Hodgkin lymphoma | 57,459 (41,974–74,380) |
60.23 (45.53–77.24) |
85,412 (59,691–107,529) |
68.88 (50.41–85.93) |
105,391 (72,629–133,887) |
63.04 (45.26–79.08) |
122,851 (86,562–161,684) |
57.51 (41.62–75.57) |
2.67 (2.61–2.72) |
| Kidney cancer | 13,110 (10,753–16,621) |
17.58 (14.49–21.21) |
21,602 (17,570–26,277) |
24.86 (21.41–29.31) |
31,826 (25,202–39,663) |
28.75 (23.26–35.71) |
44,131 (33,808–58,932) |
30.95 (23.5–41.47) |
4.33 (4.27–4.41) |
| Larynx cancer | 97,326 (81,027–116,131) |
159.62 (132.98–190.39) |
143,876 (122,546–167,576) |
194.59 (165.59–226.27) |
167,204 (132,804–206,065) |
173.34 (138.54–213.09) |
200,054 (153,489–264,943) |
155.08 (119.63–203.66) |
2.55 (2.52–2.59) |
| Leukemia | 195,066 (118,387–293,639) |
157.38 (112.13–209.06) |
254,966 (181,729–356,229) |
173.82 (137.71–220.96) |
306,782 (233,892–394,884) |
166.83 (134.57–204.08) |
363,565 (290,877–449,774) |
164.17 (134.44–198.88) |
2.21 (2.1–2.3) |
| Lip and oral cavity cancer | 222,000 (188,451–262,436) |
343.14 (293.41–405.54) |
354,194 (307,565–405,176) |
441.29 (382.48–504.58) |
453,821 (378,474–543,346) |
430.09 (361.61–513.01) |
594,089 (471,317–754,897) |
421.87 (338.19–535.02) |
3.45 (3.42–3.48) |
| Liver cancer | 64,587 (47,309–84,080) |
91.77 (63.93–122.11) |
85,075 (69,774–102,029) |
101.48 (80.91–124.33) |
106,355 (87,421–125,805) |
98.05 (78.27–118.19) |
129,034 (104,785–157,625) |
91.09 (73.72–112.15) |
2.45 (2.42–2.49) |
| Malignant skin melanoma | 7,829 (5,670–10,053) |
11.06 (8.18–14.02) |
11,706 (7,579–14,845) |
13.21 (8.83–16.36) |
15,103 (9,622–18,813) |
12.89 (8.58–16) |
19,920 (12,886–26,235) |
12.87 (8.37–16.85) |
3.27 (3.24–3.3) |
| Mesothelioma | 2,054 (1,064–3,589) |
3.15 (1.67–5.63) |
3,333 (1,845–5,970) |
4.18 (2.41–7.2) |
4,416 (2,613–7,400) |
4.28 (2.64–6.95) |
5,904 (3,503–9,531) |
4.32 (2.64–6.78) |
3.72 (3.69–3.74) |
| Multiple myeloma | 18,661 (15,288–23,349) |
31.37 (25.5–39.4) |
26,423 (21,203–31,382) |
37.34 (29.8–43.92) |
34,184 (27,351–41,880) |
37.49 (29.39–45.71) |
45,287 (33,714–57,255) |
37.23 (27.61–46.49) |
3.11 (3.08–3.14) |
| Nasopharynx cancer | 32,396 (27,566–37,064) |
46.51 (39.57–53.31) |
45,741 (39,388–52,862) |
51.8 (44.4–59.9) |
57,538 (47,469–68,683) |
48.74 (40.17–58.39) |
71,647 (57,194–88,599) |
45.65 (36.3–57.03) |
2.79 (2.76–2.82) |
| Non-Hodgkin lymphoma | 41,518 (25,573–58,531) |
47.02 (31.63–62.24) |
67,065 (40,191–96,740) |
61.32 (39.24–85.45) |
93,632 (55,664–138,747) |
65.97 (41.25–96.76) |
122,027 (77,460–178,060) |
67.09 (44.73–96.9) |
3.83 (3.76–3.91) |
| Non-melanoma skin cancer (basal-cell carcinoma) | 0 (0–1) | 0 (0–0) | 0 (0–1) | 0 (0–0) | 0 (0–1) | 0 (0–0) | 1 (0–1) | 0 (0–0) | 3.05 (3.05–3.06) |
| Non-melanoma skin cancer (squamous-cell carcinoma) | 4,451 (2,494–6,033) |
7.88 (4.3–10.72) |
5,386 (3,903–6,827) |
8.23 (5.71–10.41) |
6,551 (4,899–8,431) |
7.88 (5.78–10.07) |
8,461 (6,470–10,953) |
7.65 (5.68–9.87) |
2.23 (2.21–2.26) |
| Other leukemia | 55,545 (21,606–102,315) |
40.44 (19.22–66.14) |
59,682 (30,399–103,529) |
37.71 (22.21–57.3) |
59,712 (36,841–92,201) |
31.39 (21.55–44.93) |
63,093 (42,445–93,641) |
28.27 (20.15–39.41) |
0.48 (0.38–0.57) |
| Other pharynx cancer | 55,836 (46,823–66,945) |
89.28 (74.67–107.28) |
87,425 (75,528–102,164) |
113.56 (97.76–132.4) |
113,016 (91,181–139,624) |
111.86 (90.43–138.18) |
148,444 (114,299–193,527) |
109.78 (84.18–143.17) |
3.45 (3.42–3.48) |
| Ovarian cancer | 46,538 (35,377–57,205) |
70.03 (54.01–86.55) |
78,814 (57,332–97,120) |
96.28 (73.52–118.43) |
142,832 (93,099–197,498) |
132.98 (88.59–183.56) |
241,404 (122,744–390,862) |
168.77 (88.55–272.27) |
5.85 (5.81–5.88) |
| Pancreatic cancer | 20,993 (17,490–24,304) |
35.74 (29.84–41.53) |
34,130 (29,742–38,993) |
49.38 (42.99–56.3) |
54,812 (44,649–66,104) |
62.05 (50.57–74.82) |
81,818 (63,158–105,869) |
69.62 (54.01–89.47) |
4.87 (4.81–4.93) |
| Prostate cancer | 50,396 (36,066–67,442) |
97.18 (70.1–131.84) |
61,536 (45,036–73,236) |
109.08 (80.99–130.05) |
72,654 (51,906–93,000) |
105.21 (77.33–132.82) |
95,910 (68,727–127,158) |
104.52 (76.74–136.75) |
2.23 (2.2–2.27) |
| Stomach cancer | 100,449 (82,664–117,355) |
165.67 (134.8–193.87) |
149,096 (130,092–168,468) |
203.33 (176.76–230.39) |
176,558 (146,456–207,219) |
186.66 (155.83–218.04) |
204,475 (166,415–252,396) |
162.7 (133.94–198.78) |
2.5 (2.48–2.53) |
| Testicular cancer | 15,079 (12,454–18,471) |
15.46 (12.55–18.87) |
24,700 (20,058–30,491) |
19.3 (15.69–23.5) |
33,813 (25,146–44,678) |
19.89 (14.72–26.14) |
45,891 (32,596–64,455) |
21.06 (14.99–29.52) |
3.9 (3.86–3.94) |
| Thyroid cancer | 16,908 (14,563–19,904) |
23.94 (20.77–28.23) |
29,276 (24,423–33,728) |
33.09 (28.17–37.62) |
38,327 (31,722–45,824) |
33.09 (27.77–39.04) |
49,409 (39,271–60,858) |
32.29 (26.35–39.3) |
3.78 (3.75–3.81) |
| Tracheal, bronchus, and lung cancer | 214,427 (181,841–248,653) |
361.3 (305.47–420.49) |
329,901 (280,892–383,936) |
464.18 (396.05–540.62) |
416,861 (321,808–524,148) |
453.8 (350.78–567.63) |
522,648 (400,317–680,663) |
425.72 (327.1–550.78) |
3.12 (3.08–3.15) |
| Uterine cancer | 23,279 (18,943–30,326) |
38.76 (31.29–51.64) |
39,787 (31,321–48,984) |
55.23 (44.04–68.79) |
53,056 (39,595–67,954) |
57.58 (43.88–73.33) |
71,084 (50,858–96,356) |
58.1 (43–79.74) |
3.93 (3.9–3.97) |
| Geographical area | |||||||||
| Pakistan | 2,414,828 (2,105,713–2,713,915) |
3,363.75 (3,000.28–3,703.96) |
3,639,168 (3,254,522–4,068,820) |
4,224.26 (3,778.87–4,628.45) |
4,778,563 (4,102,144–5,528,207) |
4,270.8 (3,693.01–4,935.43) |
6,268,083 (5,269,382–7,399,739) |
3,439.9 (2,871.7–4,122.04) |
0.85 (0.82–0.88) |
| Sindh | 412,712 (328,106–499,818) |
2,957.09 (2,373.6–3,596.82) |
714,569 (570,005–871,910) |
4,054.54 (3,246.45–4,955.59) |
944,447 (741,185–1,181,726) |
4,011.3 (3,191.94–5,042.02) |
1,221,334 (944,552–1,553,931) |
3,330.1 (2,540.4–4,239.04) |
0.99 (0.96–1.03) |
| Punjab | 1,548,329 (1,336,942–1,781,591) |
3,710.68 (3,252.72–4,189.82) |
2,200,970 (1,878,003–2,523,407) |
4,485.13 (3,904.54–5,071.07) |
2,853,279 (2,365,471–3,395,420) |
4,542.35 (3,784.06–5,384.21) |
3,717,719 (2,978,642–4,505,382) |
3,538.2 (2,855.7–4,316.5) |
0.75 (0.73–0.77) |
| Khyber Pakhtunkhwa | 274,439 (198,997–352,757) |
2,700.42 (1,969.82–3,471.02) |
432,515 (337,452–536,418) |
3,458.43 (2,689.88–4,296.31) |
596,704 (470,273–744,613) |
3,640.96 (2,845.62–4,569.96) |
796,705 (626,009–1,020,083) |
3,239.2 (2,474.3–4,209.5) |
1.07 (1.05–1.1) |
| Islamabad Capital Territory | 9,329 (6,195–11,926) |
3,042.17 (2,150.54–3,866.46) |
18,133 (14,105–22,468) |
3,970.52 (3,092.71–4,929.98) |
28,721 (21,936–37,054) |
4,043.23 (3,114.16–5,144.03) |
44,480 (32,780–58,729) |
3,053.8 (2,116.2–3,968.3) | 0.91 (0.87–0.95) |
| Gilgit-Baltistan | 12,500 (8,044–17,185) | 2,839.69 (2,009.65–3,773.29) | 23,099 (17,683–29,091) | 3,866.88 (2,991.95–4,858.32) | 32,159 (24,165–41,676) | 3,817.19 (2,868.72–4,956.81) | 43,960 (32,632–56,773) | 3,440.3 (2,513.5–4,557.9) | 0.96 (0.92–1.01) |
| Balochistan | 105,033 (61,585–134,814) | 3,248.15 (2,067.81–4,117.22) | 168,674 (131,570–213,844) | 4,478.91 (3,501.89–5,648.68) | 224,774 (174,872–286,768) | 4,492.57 (3,484.52–5,721.2) | 318,498 (244,064–403,820) | 3,552.41 (2,636.6–4,685.9) | 1.12 (1.08–1.17) |
| Azad Jammu & Kashmir | 52,486 (41,918–65,159) | 3,236.5 (2,599.24–4,016.64) | 81,208 (63,723–101,009) | 4,256.25 (3,321.24–5,308.68) | 98,480 (76,028–126,715) | 4,241.82 (3,286–5,478.07) | 125,386 (93,958–162,886) | 3,615.4 (2,774.1–4,890.4) | 0.93 (0.91–0.95) |
| Gender | |||||||||
| Male | 1,302,256 (1,070,186–1,566,355) | 3,366.94 (2,873.63–3,880.13) | 1,896,622 (1,586,151–2,247,881) | 4,184.5 (3,552.91–4,856.13) | 2,415,328 (1,898,787–2,963,666) | 4,159.12 (3,296.71–5,092.04) | 3,044,786 (2,387,913–3,877,694) | 3,197.6 (2,143.8–4,581.02) | 0.67 (0.64–0.69) |
| Female | 1,112,572 (953,585–1,288,436) | 3,333.34 (2,827.51–3,899.6) | 1,742,546 (1,526,071–1,957,327) | 4,256.1 (3,704.35–4,795.38) | 2,363,235 (1,945,354–2,834,300) | 4,390.68 (3,607.41–5,251.79) | 3,223,297 (2,485,198–4,134,247) | 4,012.8 (2,680.9–5,879.07) | 1.07 (1.04–1.09) |
| Total | 2,414,828 | 3,639,168 | 4,778,563 | 6,268,083 | |||||