Table 2.
Co-prevalence of the different pfk13 (Y493H, R561H and A675V) and pfmdr1 (N86Y, Y184F and D1246Y) SNPs and haplotypes.
| Transmission profile | District | Region | Village | PfK13-PfMDR1 SNPs and haplotypes, n (%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wild-type YRA-NYD | Sensitive* YRA-NFD | Sensitive YRA-NYY | Sensitive YRA-NFY | ART-R** YHA-NYD | ART-R YRV-NYD | AL-R*** HRA-NFD | AL-R YHA-NFD | AL-R YRV-NFD | ||||
| High transmission | Geita | Chato | Ihanga (n = 111) | 34 (30.6) | 74 (66.7) | – | – | – | – | – | 2 (1.8) | 1 (0.9) |
| Rwantaba (n = 112) | 56 (50.0) | 50 (44.6) | 2 (1.8) | – | – | 3 (2.7) | – | – | 1 (0.9) | |||
| Nyang’hwale | Kayenze (n = 79) | 16 (20.3) | 57 (72.1) | – | 3 (3.8) | – | – | 2 (2.5) | 1 (1.3) | – | ||
| Nyangalamila (n = 76) | 41 (53.9) | 35 (46.1) | – | – | – | – | – | – | – | |||
| Kigoma | Kasulu | Mugombe (n = 109) | 64 (58.7) | 43 (39.5) | – | – | – | 1 (0.9) | – | 1 (0.9) | – | |
| Nyamnyusi (n = 96) | 65 (67.7) | 28 (29.2) | 2 (2.1) | 1 (1.0) | – | – | – | – | – | |||
| Kibondo | Bunyambo (n = 97) | 61 (62.9) | 34 (35.1) | 1 (1.0) | 1 (1.0) | – | – | – | – | – | ||
| Kumuhasha (n = 91) | 41 (45.1) | 38 (41.8) | – | – | 9 (9.9) | – | – | 3 (3.3) | – | |||
| Sub total (n = 771) | 378 (49.0) | 359 (46.6) | 5 (0.6) | 5 (0.6) | 9 (1.2) | 4 (0.5) | 2 (0.3) | 7 (0.9) | 2 (0.3) | |||
| Low transmission | Arusha | Arusha DC | Bwawani (n = 14) | 6 (42.9) | 7 (50.0) | 1 (7.1) | – | – | – | – | – | – |
| Themi ya simba | ||||||||||||
| (n = 9) | 5 (55.6) | 4 (44.4) | - | – | – | – | – | – | – | |||
| Meru | Maji ya chai (n = 5) | 2 (40.0) | 3 (60.0) | – | – | – | – | – | – | – | ||
| Ngurudoto (n = 5) | 4 (80.0) | 1 (20.0) | – | – | – | – | – | – | – | |||
| Sub total (n = 31) | 15 (48.4) | 15 (48.4) | 1 (3.2) | |||||||||
| TOTAL (n = 802) | 393 (49.0) | 374 (46.6) | 6 (0.7) | 5 (0.6) | 9 (1.1) | 4 (0.5) | 2 (0.2) | 7 (0.9) | 2 (0.2) | |||
*Indicate isolates with mutant SNPs in both pfk13 and pfmdr1 genes.
Bold letters indicate mutant codons.