Table 3.
Median (interquartile range), Mann-Whitney derived p values and AUC (95% CI) for all plotted values comparing the ability of the IBD disk and traditional disease activity index to differentiate CD and UC patients who will/will not require advanced therapies, surgical resections or inpatient care within the first 12 months, in addition to the rates of persistent disease activity at the 12-month timepoint.
| Treatment Outcome | UC (n=84) | CD (n=95) | ||
|---|---|---|---|---|
| Partial mayo | IBD disk | Harvey bradshaw index | IBD disk | |
| Advanced therapy within 12m UC AT 18/84 (21%) CD AT 49/95 (52%) |
No AT: 4 (2) | No AT: 40 (31.5) | No AT: 6 (4) | No AT: 53 (29.25) |
| AT: 7 (2) | AT: 54.5 (24.5) | AT: 9 (4) | AT: 65 (29) | |
| p<.001 | p=0.019 | p=<.001 | p=0.014 | |
| AUC 0.853 (0.744-0.962) | AUC 0.681 (0.539–0.824) | AUC 0.760 (0.658–0.862) | AUC 0.646 (0.534–0.758) | |
| Active disease at 12m UC Active 19/84 (23%) CD Active 37/95 (39%) |
Inactive: 4 (3) | Inactive 41 (33) | Inactive: 7 (5) | Inactive: 54 (32) |
| Active: 6 (3) | Active: 54 (31.5) | Active: 9 (5) | Active: 62 (27) | |
| p=0.013 | p=0.023 | p=0.014 | p=0.015 | |
| AUC 0.689 (0.559 – 0.819) | AUC 0.672 (0.527–0.817) | AUC 0.653 (0.541–0.765) | AUC 0.649 (0.537–0.761) | |
| Inpatient care during first 12m UC IP care 18/84 (21%) CD IP care 15/95 (16%) |
No IP care: 3 (2) | No IP care: 40 (28.25) | No IP care: 7 (4) | No IP care: 56 (26.75) |
| IP care: 7 (1) | IP care: 66.5 (29) | IP care: 9 (3.5) | IP care: 58 (26.5) | |
| p<.001 | p<.001 | p=0.199 | p=0.366 | |
| AUC 0.937 (0.885 – 0.989) | AUC 0.827 (0.719 – 0.934) | AUC 0.605 (0.466 – 0.744) | AUC 0.574 (0.412 – 0.736) | |
| Resection within 12m UC resection 2/84 (2%) CD resection 7/95 (7%) |
No resection: 4 (3) | No resection: 42 (34) | No resection: 8 (4) | No resection: 56 (26.75) |
| Resection: 7 (0) | Resection: 59 (4) | Resection: 7 (4.5) | Resection: 77 (26.5) | |
| p=0.510 | p=0.064 | |||
| Only 2 patients | Only 2 patients | AUC 0.576 | AUC 0.712 | |