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. 2026 Feb 9;16:7919. doi: 10.1038/s41598-026-38654-w

Table 3.

Literature review: XAI studies using ECG signals.

References Database ECG input types Target Class Deep method + explainability Performance
Signal Cho et al.22 Clinical data

6-lead Signals

12-Lead Signals

MI Detection Normal and MI CNN + GradCAM

AUC: 0.880

AUC: 0.854

Wang et al.16

MIT-BIH ADB

PTB-XL DB

Lead II

Lead I, II, V1, V2, V3, V6

ECG Beat Classification N, S, V, F, Q ResNet + GradCAM Acc: 98.64%
Hicks et al.23 Inter99 DB 12-Lead Signals Sex Prediction Male, Female CNN + GradCAM Acc: 88.08%
Ma et al.27 MIMIC-III DB

PPG Signals,

Lead II Signals

Blood Pressure Prediction SBP and DBP AlexNet, GoogLeNet, ResNet18, DenseNet121, DPN68

DenseNet121:

MAE: 3.69, 1.95

RMSE: 5.18, 2.71

Jahmunah et al.24 PTB DB 12-Lead Signals MI Detection Normal and 10 types of MI

CNN + GradCAM

DenseNet + GradCAM

Acc: 98.9%
Anand et al.25

PTB-XL DB

Chapman

12-Lead Signals

- MI Detection

- Arrhythmia Classification

5 types of MI

AFib, GSVT, SB, SR

CNN + SHAP

AUC: 93.41%

AUC: 99.46%

Singh et al.32 MIT-BIH ADB Beat Signals Arrhythmia Classification 6 types of Arrhythmia

CNN + ECANet

 + K-GradCAM

Acc: 98.88%
Kim et al.17 Clinical data Lead II Signals Arrhythmia Detection Normal and Arrhythmia DenseNet + GradCAM Acc: 98.71%
Han et al.26

PTB DB

PTB-XL DB

12-Lead Signals MI Detection and Localization Normal and 5 types of MI ResNet + GradCAM

Acc: 99.97%

Acc: 99.85%

Loh et al.33 Clinical data Segmented Raw ECG Signals ADHD and CD Detection ADHD, CD, ADHD + CD CNN + GradCAM Acc: 96.04%
Le et al.19 Chapman, CPSC Lead I, II, V1 ECG Signals Arrhythmia Classification 13 types of Arrhythmia 1DSEResNet + GradCAM

F1 Score: 0.9718

F1 Score: 0.8004

Image Makimoto et al.31 PTB DB 9-Lead PNG formatted Images MI Detection Normal and MI CNN + GradCAM Acc: 87.5% ± 11.8%
Sangha et al.28

CODE study

PTB-XL DB

12-Lead PNG formatted Images Multilabel Prediction Male and 6 types of Arrhythmia EfficientNet + GradCAM

AUC: 0.99

AUC: 0.97

Fang et al.29

PTB DB

PTB-XL DB

12-Lead 3-D ECG Images MI Detection Normal and MI CNN + GradCAM

Acc: 95.65%

Acc: 97.23%

Varandas et al.20 MIT-BIH ADB Lead II, V5 ECG Images Arrhythmia Detection Normal and Arrhythmia ResNet50 + GB GradCAM

Acc: 93.66%

Acc: 91.72%

Kondo et al.18 Clinical data

Lead II, V3, V5, aVR

ECG Images

CCU Mortality Prediction CCU Survivors and Non-survivor

CNN + 

GradCAM

Acc: 77.3%
Ao et al.30

PTB-XL DB, CPSC,

Chapman, Tongji

12-Lead ECG Images Arrhythmia Classification Diagnoses of 15 types VGG16 + GradCAM AUC: 0.982
Image + Signal Our study Chapman21 Lead II Arrhythmia Classification AFib, GSVT, SB, SR CNN + MM-GradCAM

Signal Form: Acc: 93.07%

Image Form: Acc: 97.44%

Acc: Accuracy, Sen: Sensitivity, Spec: Specificity, AUC: area under the receiver operating characteristics curve, N: non-ectopic, S: supraventricular ectopic, V: ventricular ectopic, F: Fusion, Q: Unknown, SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, MAE: Mean Absolute Error, RMSE: Root Mean Square Error, ADHD: Attention Deficit Hyperactivity Disorder, CD: Conduct Disorder, CCU: Cardiac Care Unit.