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. 2026 Feb 9;14(3):e02151-25. doi: 10.1128/spectrum.02151-25

Fig 5.

Drug sensitivity analysis in STAD showing NMDS patterns across immunophenotypes, Manhattan plot highlighting ICB response compounds, forest plot of biomarkers, and a correlation heatmap linking INC subtypes with immune cells.

Analysis of drug sensitivity and potential therapeutic targets associated with immunophenotypes in STAD. (a) NMDS analysis illustrates the differential distribution patterns of drug sensitivity across immune-related NMF clusters (INC) subtypes. (b) Manhattan plot displaying statistical significance and effect sizes (Cliff’s delta) for 198 compounds, highlighting 106 compounds with significant differences in drug sensitivity between ICB R and NR after FDR correction. (c) Forest plot showing the top 10 most robust biomarkers associated with drug sensitivity and ICB response, identified via multivariate logistic regression adjusting for confounders such as INC subtype, tumor purity, and tumor stage. (d) Boxplots depicting the differences of the top 30 drugs among INC subtypes, alongside a correlation heatmap illustrating the associations between INC subtypes and 24 immune cell types.