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. 2026 Feb 18;17:1763837. doi: 10.3389/fphys.2026.1763837

FIGURE 2.

Multi-panel scientific figure showing gene expression analysis results: Panel a displays twelve line graphs of gene expression changes over four time points, each labeled as a different cluster with shaded confidence intervals. Panel b presents a horizontal bar graph of gene counts showing up-regulated (orange) and down-regulated (teal) genes in phases P1, P2, and P3. Panel c is a matrix plot listing gene sets by row and phases by column, color-coded for significance as NES greater than 1 (orange), NES less than 1 (teal), or no significance (gray).

The results of the time series analysis, DEGs and HGSEA among DAHA groups. (a) Line plot presenting the results of the time series analysis, where genes were divided into 12 clusters. Red lines represent the dominant expression trend within each cluster across DAHA groups. (b) Bar chart illustrating the counts of DEGs in 3 periods (P1, P2 and P3). Orang bars: upregulated genes, Turquoise bars: downregulated genes. (c) Heatmap displaying the HGSEA results of 3 periods (P1, P2 and P3). Orange tiles: upregulated pathway (NES >1), Turquoise tiles: downregulated pathway (NES <1), Gray tiles: no significance pathway. Note: DAHA: days of acclimatization at high altitude; DEGs: differentially expressed genes; HGSEA: hallmark gene set enrichment analysis; P1: period 1 (T2 vs. T1); P2: period 1 (T3 vs. T2); P3: period 1 (T4 vs. T3); NES: normalized enrichment score.