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. 2026 Feb 18;17:1763837. doi: 10.3389/fphys.2026.1763837

FIGURE 4.

Venn diagram, bar chart, enrichment plot, and heatmap panels compare gene expression patterns. Panel a shows intersections of gene sets for patterns one and two, up- and down-regulated genes. Panel b presents green color-coded bar chart for enriched biological processes with labels and significance. Panel c displays enrichment score curves for eight gene sets across an ordered dataset. Panel d shows a heatmap with marked significant genes in biological pathways for each group, with red indicating significance.

Gene set counts, overlaps, and enrichment analyzes of DEGs and GEPs. (a) Venn diagram showing the overlap between the eAMS + group, the eAMS- group, Pattern 1 and Pattern 2. (b) Heatmap showing the enrichment analysis results for the upregulated and downregulated genes between the eAMS+ and eAMS- groups, as well as for the genes in Pattern 1 and Pattern 2. Green tiles indicate the significant pathways and the depth of color represents the -logP value. (c) HGSEA curve plot presenting the significant hallmark genesets pathways comparing the eAMS+ and eAMS- groups. (d) Heatmap displaying the HGSEA results for the upregulated and downregulated genes between the eAMS+ and eAMS- groups, as well as for the genes in Pattern 1 and Pattern 2. The red box indicates significant results, and the gray box suggests no significance.