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. 2026 Feb 18;17:1763837. doi: 10.3389/fphys.2026.1763837

FIGURE 5.

Figure composed of three panels: (a) schematic and Venn diagram comparing up-regulated genes from two studies on altitude adaptation, plus a line chart showing gene expression patterns over time; (b) network illustration of gene ontology clusters with color-coded legend; (c) bar plot and upset plot displaying intersection sizes for differentially expressed gene sets.

Changes in gene expression from low altitude to high altitude in Pattern 2. (a) Trends and counts of upregulated genes in GSE75665 and in Pattern 2 identified in our study. Pink: data from GSE75665, Darkblue: data from our study. (b) Enrichment analysis results for the genes shared between the upregulated genes in GSE75665 and Pattern 2 from our study. (c) UpSetR plot showing gene sets of Pattern 1, Pattern 2, hub genes in Patterns 1 and 2, DEGs from sea level and high altitude in dataset GSE75665, and their overlaps.