Table 5.
Biocompatibility and degradation rate of PMMA and PLA-based nanocomposites.
| Author and Year | Biocompatibility Assessment Method | Results | Degradation Rate (% weight loss over time) |
|---|---|---|---|
| Kamonkhantikul et al., 2017 (10). | Cell viability assays (MTT, Live/Dead staining) | High cell viability, minimal cytotoxicity | 5% - 10% weight loss over 6 months |
| Shafiee Nasab et al. 2018 (20). | ISO 10993 cytotoxicity test | Non-cytotoxic | 2% over 6 months |
| Lipovsky et al., 2011 (15). | In vitro cytotoxicity tests, In vivo animal studies, Histological analysis | No significant cytotoxicity observed, | 0.5% after 6 months, |
| Good tissue compatibility, No adverse reactions | 1.2% after 6 months, | ||
| 0.8% after 6 months | |||
| Mousavi et al., 2020 (15). | PMMA-Based Nanocomposites | Generally high, with good tissue integration and minimal cytotoxicity | Degrades slowly over time; rate dependent on environmental conditions and additives |
| PLA-Based Nanocomposites | |||
| Raj et al. 2018 (23). | MTT assay (cell viability assay) | Non-toxic, maintained cell viability | Slow degradation rate; minimal weight loss over the tested period |