Fig. 1.

Prediction-corrected visual predictive check of the final population pharmacokinetic model for high-dose methotrexate in adult patients with lymphoma. The solid black line represents the median observed concentration for the simulation (N = 1000). The gray shaded area is the median prediction interval. The dashed black lines represent the 10th and 90th percentiles of the observed concentrations. The shaded blue areas represent the 10th and 90th percentiles of the prediction intervals. The ‘•’ are observed patient data. The analysis was completed in Pirana using the automatic binning algorithm. The figure was created using NONMEM2R (CRAN, Version 0.2.5)