Table 2.

Final population pharmacokinetic model parameters for high-dose methotrexate in adult patients with lymphoma

Parameters	Final model			Bootstrap
	Estimate	RSE (%)	Shrinkage (%)	Median	95% CI
CL (L/h)	11.8	5.1		11.8	10.8–12.8
ΘeGFR	0.80	11.5		0.79	0.64–0.95
ΘAlbumin	0.69	21.3		0.67	0.42–0.97
V1 (L)	42.2	6.4		41.9	37.8–46.5
Q (L/h)	0.35	11.6		0.35	0.29–0.43
V2 (L)	6.67	10.4		6.63	5.56–7.88
IIV CL	0.02	24.3	13.3	0.02	0.01–0.03
IIV V2	0.03	23.9	31	0.03	0.02–0.05
Residual error	0.20	11.6	12.2	0.20	0.16–0.23

IIV and residual error are reported as the variance of the selected parameter

CI confidence interval, CL clearance, eGFR estimated glomerular filtration rate, IIV inter-individual variability, Q intercompartmental clearance, RSE relative standard error, V1 volume of distribution of the central compartment, V2 volume of distribution of the peripheral compartment