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. 2026 Jan 29;65(3):465–477. doi: 10.1007/s40262-026-01618-4

Table 4.

Model estimated 4-h serum MTX concentration by dose and AKI status

Treatment groups AKI (N = 17) No AKI (N = 63) Row total
MTX dose: ≤ 3.5 g/m2; N = 43 182.8 (153.4–241.8) 116.2 (78.1–150.9) 129.2 (84.1–178.8)
MTX dose: 8 g/m2; N = 37 335.6 (265.4–479.6) 313.3 (231.5–385.1) 315.7 (240.2–534.5)

Model estimated MTX concentrations (µmol/L) are reported median (interquartile range)

AKI acute kidney injury, MTX methotrexate