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. 2026 Mar 2;16:8147. doi: 10.1038/s41598-025-34505-2

Table 15.

Operational linkage of statistical Metrics.

Statistical Metric Computation Source Decision Threshold Operational Impact
Hybrid t-test (p-value) 10,000 Monte Carlo (Section "Statistical method performance.Statistical method performance") p < 0.001 Model retention in ensemble; reject if violated
Cohen’s d effect size Heatmap (Fig. 7) d ≥ 0.8 (large); decline > 0.2 Prioritize weighting; trigger adaptive retraining
Cross-Dataset Robustness Index (CRI) Equation 18 (Table 14) CRI ≥ 0.98 Full ensemble contribution; else partial fine-tuning
Variance ratio (heteroscedasticity) Bootstrap distributions Ratio > 2:1 Temporary confidence down-weighting in ensemble
Longitudinal drift Monthly effect-size tracking d shift > 0.2 or p rise > 0.05 Activate adaptive learning rule (Eq. 4)