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. 2026 Mar 6;16(14):12663–12681. doi: 10.1039/d5ra08490c

Table 2. Comparison between thermoplastics and glass. Adapted with permission from ref. 34. Copyright 2013 American Chemical Society.

Optics Standard thermoplastics Glass
Transparency Good Good
Autofluorescence Low (the right polymer choice is important) Low
Application in the UV region In near UV, special polymers are available Quartz glass needs to be chosen
Surface roughness Can be optically smooth Depending on technology
Thermal stability Depending on the polymer choice, 100 °C is possible Approximately 600 °C transition to the liquid phase
Stability against organic solvents Limited High
Stability against standard solvents in life sciences Polymers available High
Stability against basic solutions High Medium
Stability against acidic solutions High High
Unspecific binding of biological components Polymers with low unspecific binding are available, and surface functionalization to avoid the issue is available High, surface functionalization to avoid the issue available