Fig. 3.

Expression and enrichment of EP300-correlated genes (Module 1 = positive; Module 2 = negative). (A) heatmap shows Z-score expression of EP300-related genes across EP300-high/low samples; (B) Module 1 (positive) is enriched for oxidative phosphorylation, respiratory chain/respirasome and mitochondrial inner membrane terms, indicating coordinated OXPHOS upregulation in EP300-high tumors; (C) Module 2 (negative) is enriched for transcriptional coregulation, histone acetyl-/methyltransferase complexes, SWI/SNF-like complex, nuclear speck and pathways including actin cytoskeleton regulation, neurotrophin and thyroid hormone signaling and lysine degradation, suggesting a collective downtrend when EP300 is elevated. Multiple-testing adjusted p values are reported