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Upregulation in tissues and siRNA knockdown validation. (A) qRT-PCR in ten paired HCC tumors and adjacent tissues shows higher EP300 in tumors (***p < 0.001); (B–C) in SK-hep-1 and Huh-7, si-EP300-1/-4 achieve the strongest mRNA knockdown; (D–E) Western blots confirm consistent protein reduction with si-EP300-1/-4 (GAPDH-adjusted; multiple comparisons significant). Data are mean±SEM
