Table 1.
Cox proportional hazards models evaluating the impact of EP300 and clinical covariates on overall survival (univariate and multivariable)
| Characteristics | Total(N) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |||
| EP300 | 370 | |||||
| Low | 184 | Reference | Reference | |||
| High | 186 | 1.383 (0.977 - 1.958) | 0.067 | 1.164 (0.740 - 1.832) | 0.511 | |
| Pathologic T stage | 367 | |||||
| T1 | 181 | Reference | Reference | |||
| T2 | 93 | 1.436 (0.906 - 2.276) | 0.124 | 1.528 (0.836 - 2.793) | 0.168 | |
| T3 | 80 | 2.615 (1.723 - 3.970) | < 0.001 | 2.523 (1.461 - 4.358) | < 0.001 | |
| T4 | 13 | 5.294 (2.644 - 10.599) | < 0.001 | 4.907 (1.801 - 13.368) | 0.002 | |
| Pathologic M stage | 270 | |||||
| M0 | 266 | Reference | Reference | |||
| M1 | 4 | 4.032 (1.267 - 12.831) | 0.018 | 0.747 (0.143 - 3.912) | 0.730 | |
| Tumor status | 351 | |||||
| Tumor free | 201 | Reference | Reference | |||
| With tumor | 150 | 2.361 (1.620 - 3.441) | < 0.001 | 1.965 (1.225 - 3.153) | 0.005 | |