Table 2.

Hazard ratios (95% CIs) of the risk of incident UC, CD and IBD in relation to LC9

		Continuous		Low CVH (0–49)	Moderate CVH (50–79)		High CVH (80–100)
		HR 95%CI	P-value		HR 95%CI	P-value	HR%95CI	P-value	P for trend
UC	Model 1	0.872(0.830 ~ 0.915)	< 0.001	Ref.	0.755(0.670 ~ 0.851)	< 0.001	0.948(0.718 ~ 1.251)	0.705	0.001
	Model 2	0.907(0.862 ~ 0.955)	< 0.001	Ref.	0.804(0.712 ~ 0.907)	< 0.001	1.114(0.841 ~ 1.476)	0.453	0.027
	Model 3	0.909(0.863 ~ 0.958)	< 0.001	Ref.	0.805(0.712 ~ 0.910)	0.001	1.146(0.862 ~ 1.523)	0.349	0.036
CD	Model 1	0.912(0.847 ~ 0.981)	0.014	Ref.	0.867(0.720 ~ 1.045)	0.135	1.051(0.690 ~ 1.601)	0.818	0.358
	Model 2	0.904(0.838 ~ 0.976)	0.010	Ref.	0.868(0.718 ~ 1.050)	0.144	1.042(0.680 ~ 1.598)	0.849	0.361
	Model 3	0.928(0.858 ~ 1.003)	0.059	Ref.	0.904(0.745 ~ 1.097)	0.305	1.146(0.746 ~ 1.761)	0.535	0.684
IBD	Model 1	0.956(0.934 ~ 0.979)	< 0.001	Ref.	0.874(0.824 ~ 0.928)	< 0.001	0.835(0.720 ~ 0.967)	0.016	< 0.001
	Model 2	0.960(0.937 ~ 0.983)	0.001	Ref.	0.883(0.831 ~ 0.937)	< 0.001	0.850(0.732 ~ 0.987)	0.033	< 0.001
	Model 3	0.976(0.953 ~ 1.001)	0.060	Ref.	0.911(0.857 ~ 0.969)	0.003	0.902(0.775 ~ 1.050)	0.184	0.005

Model 1, No covariates were adjusted; Model 2 included additional adjustments for age, sex and race. Model 3 further adjusted for educational score and TDI based on Model 2 adjustments

Abbreviations: CI Confidence Intervals, CVH Cardiovascular Health, HR Hazard ratios, IBD Inflammatory Bowel Disease, LC9 Life’s Critical 9, SD Standard Deviation, TDI Townsend Deprivation Index; UC, Ulcerative Colitis;

Bold P-values indicate statistical significance (P < 0.05)