Table 3.
Univariate and multivariate analysis for risk factors and outcomes (OS and PFS)
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| OS OR, [95%]CI, P |
PFS OR, CI%, P |
OS OR, CI%, P |
PFS OR, CI%, P |
||
| Factor | Comparison | ||||
| Patient and disease related characteristics | |||||
| Age (years) KPS Sex Time to Diagnosis CVRF Location Chang (T) Chang (M) CSF spread Spinal involvement ANOCEF EURACAN Histology Molecular |
<30 vs ≥30 ≥80 vs <80 Female vs male <1 month vs ≥1 month Absent vs present Lateral vs other* T1-T3a vs ≥T3b M0-M1 vs ≥M2 No vs yes (M1) No vs yes Intermediate vs high risk Intermediate vs high risk Non LCA vs LCA SHH/WNT vs non-SHH/non-WNT SHH vs others SHH TP53wt vs SHH TP53mut |
0.70, [0.35-1.41], .318 1.95[0.71-5.23], .184 1.33 [0.65-2.69], .435 0.54[0.27-1.07], .07 0.81[0.49-1.35], .416 1.67[0.83-3.39], .153 0.83[0.29-2.36], .73 3.68[1.63-8.32], .002 1.20[0.82-1.72], .362 1.22[0.80-1.85], .363 0.91[0.45-1.82], .785 1.14[0.57-2.28], .719 0.72[0.10-5.26], .743 2.01[0.99-4.07], .05 1.59[0.79-3.19], .191 0.63[0.31-1.26], .191 |
0.75[0.37-1.54], .44 1.08[0.40-2.90], .871 1.63[0.80-3.3], .178 0.48[0.23-1.02], .057 .716[0.45-1.13], .157 1.14[0.55-2.36], .713 4.00[1.05-15.2], .042 8.11[2.88-22.8], .000 0.96[0.66-1.40], .845 1.87[1.12-3.10], .015 1.70[0.81-3.58], .157 1.70[0.81-3.58], .157 – 1.80[0.86-3.79], .120 1.07[0.53-2.14], .857 0.94[0.47-1.85], .844 |
– 2.00[0.55-7.27], .288 – 0.84[0.32-2.2], .727 – 1.67[0.57-4.88], .34 – 6.05[2.00-18.27], .001 – – – – – 5.37[0.53-53], .153 0.216[0.18-2.59], .227 |
– – 0.96 [0.365-2.55], .943 0.86[0.338-2.18], .749 0.751[0.41-1.36], .348 – 3.30[0.431-12.28], .33 9.51[1.77-51.06], .009 – 0.68[0.132-3.50], .645 – – 1.13[0.42-3.05], .806 – |
| Treatment-related characteristics | |||||
| Extent of resection Treatment Craniospinal RT Posterior Fossa RT |
Complete vs incomplete CT/RT vs surgery and/or RT ≥30 Gy vs <30 Gy ≥50 Gy vs <50 Gy |
0.95[0.456-1.99], .889 1.93[0.96-3.88], .065 1.88[0.95-3.71], .068 1.65[0.83-3.31], .155 |
1.79[1.09-5.59], .029 0.67[0.33-1.38], .284 2.00[0.96-4.18], .064 1.51[0.70-3.23], .289 |
– 5.11[1.64-15.86], 0.005 3.73[1.28-10.83], 0.015 0.78[0.296-2.06], 0.621 |
0.70[0.128-3.85], 0.684 – 1.85[0.669-5.125], 0.23 – |
Chang M, Chang’s metastasis classification; Chang T, Chang’s tumor classification; CSF, cerebrospinal fluid; CVRF, cardiovascular risk factors; HR, Hazard Ratio; KPS, Karnofsky performance scale score; NOS, not otherwise specified; OS, overall survival; PFS, progression free survival; TTD, time to diagnosis from the beginning of symptoms.
*Other: midline, mixed, multifocal, cerebellopontine angle and beyond posterior fossa.