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Feed-forward condition in aortic calcification and chronic kidney disease. Aortic calcification impairs cardiac function, reducing renal perfusion, and independently causes barotrauma through high pulse pressure, accentuating renal insufficiency. Declining renal function impairs phosphate excretion and endocrine regulation by PTH (parathyroid hormone), vitamin D, and FGF23 (fibroblast growth factor 23).
