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Pharmacokinetic profile of Selutaront in male rats.
| Subject | Tmax (h) | Cmax (nM) | AUClast (h·nM) | T1/2 (h) | Vss_obs (L/kg) | Cl_obs (L/h/kg) | MRTlast (h) | F (%) |
|---|---|---|---|---|---|---|---|---|
| Selutaront - IV 1 mg/kg | 0.083 ± 0 | 3,113 ± 81 | 1906 ± 46 | 0.528 ± 0.054 | 1.46 ± 0.06 | 2.51 ± 0.06 | 0.566 ± 0.005 | — |
| Selutaront - IG 5 mg/kg | 0.139 ± 0.096 | 3,747 ± 2011 | 4,582 ± 1,321 | 3.46 ± 4.30 | — | — | 1.89 ± 1.15 | 48.1 ± 10.3 |
