Table 2.
Comparison of perioperative variables between patients with normal and impaired liver function, mean ± SD/n (%)
|
|
NL group (n = 27)
|
IL group (n = 29)
|
P value
|
| Age (years), median (IQR) | 66 (60-74) | 71 (68-77) | 0.034a |
| Sex (men/women) | 15 (55.6)/12 (44.4) | 22 (75.9)/7 (24.1) | 0.109 |
| Indication of liver resection | 0.003b | ||
| Colorectal liver metastasis | 16 (59.3) | 9 (31.0) | |
| Hepatocellular carcinoma | 3 (11.1) | 17 (55.6) | |
| Biliary tract cancer | 4 (14.8) | 1 (3.5) | |
| Others | 4 (14.8) | 2 (6.9) | |
| Indocyanine green retention rate at 15 minutes (%), median (IQR) | 7.2 (6.2-7.8) | 14.1 (11.7-18.8) | < 0.001b |
| Kinetic indocyanine green elimination rate constant, median (IQR) | 0.175 (0.170-0.186) | 0.131 (0.111-0.143) | < 0.001b |
| Fibrosis-4 index, median (IQR) | 1.46 (1.13-2.38) | 2.48 (1.37-4.35) | 0.014a |
| Albumin-bilirubin scoring | -2.69 ± 0.08 | -2.49 ± 0.08 | 0.082 |
| Modified ALBI grade (1/2a/2b) | 15 (55.6)/10 (37.0)/2 (7.4) | 11(37.9)/8 (27.6)/10 (34.5) | 0.047a |
| Number of complete resected Couinaud segments, median (IQR) | 1 (0-2) | 0 (0-2) | 0.419 |
| Laparoscopic surgery | 10 (37.0) | 12 (41.1) | 0.740 |
| Extrahepatic bile duct resection | 2 (7.4) | 2 (6.9) | 0.941 |
| Concomitant colorectal resection | 2 (7.4) | 1 (3.5) | 0.511 |
| Operative duration (minute), median (IQR) | 297 (218-328) | 288 (224-384) | 0.850 |
| Intraoperative blood loss (mL), median (IQR) | 388 (100-641) | 290 (83.5-523) | 0.774 |
| Intraoperative red blood cell transfusion | 5 (18.5) | 6 (20.7) | 0.838 |
| Intraoperative fluid balance (mL/kg/hour), median (IQR) | 8.1 (6.4-12.0) | 8.2 (6.6-12.4) | 0.844 |
| Preoperative body weight (kg), median (IQR) | 57.7 (51.9-71.8) | 59.7 (53.3-64.2) | 1.000 |
| Maximum postoperative weight gain (%), median (IQR) | 2.4 (1.0-6.1) | 3.1 (1.5-7.5) | 0.403 |
| Complications (Clavien-Dindo grade ≥ IIIa) (%) | 4 (14.8) | 8 (27.6) | 0.245 |
a
P < 0.05.
b
P < 0.01.
Statistical analyses: Mann-Whitney U test for continuous variables, χ² or Fisher exact test for categorical variables. For normal liver group: Indocyanine green retention rate at 15 minutes (ICGR15) < 10%, and for impaired liver group: ICGR15 ≥ 10%. NL: Normal liver; IL: Impaired liver; IQR: Interquartile range; ALBI: Albumin-bilirubin.