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. Author manuscript; available in PMC: 2026 Jun 16.
Published in final edited form as: Mol Cell. 2026 Feb 24;86(5):834–850.e9. doi: 10.1016/j.molcel.2026.01.030

Figure 4: DNMT3A2/3B3 manipulates the conformation of the di-nucleosome.

Figure 4:

a-b Cryo-EM maps for the isolated 10-5-10 (a) and 10-8-10 (b) di-nucleosomes. The location of the acidic patch in each di-nucleosome is indicated with a red oval. c Consensus cryo-EM map 10-5-10 DNMT3A2/3B3 complex superimposed with the cryo-EM map of the 10-5-10 di-nucleosome alone (light blue). Movements of the lower nucleosome upon DNMT3A2/3B3 tetramer binding are indicated. d Composite cryo-EM map of the 10-8-10 DNMT3A2/3B3 complex superimposed with the 10-8-10 di-nucleosome alone depicted as a semitransparent blue surface. Movements of the lower nucleosome upon DNMT tetramer binding are indicated.