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. 2005 Dec 1;115(12):3634–3640. doi: 10.1172/JCI23626

Figure 2.

Figure 2

COX-1 but not eNOS is required for NA-induced flushing. (A–C) Original LDF recordings (A and B) and quantitative analysis of the percentage of LDF increase (C) after i.p. administration of 200 mg/kg NA indicate normal first and second peaks of the flushing response in eNOS–/– mice (B and C, black bars, n = 9) compared with wild-type littermate controls (A and C, white bars, n = 9). (D–F) Original LDF recordings (D and E) and quantitative analysis of the percentage of LDF increase (F) after administration of NA to COX-1–/– mice (E and F, black bars, n = 7) and wild-type littermates (D and F, white bars, n = 6). **P = 0.002, ***P < 0.001 vs. COX-1+/+.