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Effects of weight loss and leptin administration on circulating leptin concentrations. (A) 8 am plasma leptin concentrations at Wtinitial, Wt–10%, and Wt–10%lep. Circulating leptin concentrations were significantly lower at Wt–10%, than at Wtinitial or at Wt–10%lep. (B) Percent changes (mean ± SEM) from Wtinitial values in plasma leptin concentrations at Wt–10% and Wt–10%lep. *P < 0.05 compared with 0.
