Figure 2.

Regulation of megakaryopoiesis by cytokines, chemokines, and transcription factors. In the middle panel, a scheme based on the classical pathway of megakaryopoiesis is shown. Cytokines and chemokines that influence that process are shown on the right side as green arrows to indicate the approximate level of development at which they have their influence. Open white areas in arrows indicate levels at which the cytokine is not known to act. Blue text refers to cytokine receptors of significance in megakaryopoiesis. Transcription factors that affect megakaryopoiesis are shown on the left side, and the lilac-colored arrows indicate the approximate point of their influence. Open white areas in arrows indicate levels at which the transcription factor is not known to act. Clinically relevant diseases linked to defects of these regulators are noted in red, italicized text. CFU-GEMM, CFU, granulocyte, erythrocyte, macrophage, megakaryocyte; CFU-EM, CFU, erythrocyte, megakaryocyte; BFU-EM, burst-forming unit, erythrocyte, megakaryocyte; CFU-Meg, CFU, megakaryocyte.