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Interaction of the αIIb and β3 cytoplasmic domains. (A) Backbone ribbon diagram of the αIIbβ3 membrane-proximal cytoplasmic domain clasp showing hydrophobic and electrostatic interactions. Reproduced with permission from Cell (52). (B) Model of the changes that may occur in the clasp following talin binding to the β3 cytoplasmic domain. Adapted with permission from Proceedings of the National Academy of Sciences of the United States of America (53).
