Table 7. Functional outcomes.
| Outcome | Selenium | Placebo | Mean difference (95% CI) | P value† |
|---|---|---|---|---|
| Six-minute walk test at hospital discharge | n=16 | n=16 | ||
| Completed | 7 (43.8) | 7 (43.8) | – | – |
| Unable to perform | 3 (18.8) | 2 (12.5) | – | – |
| Refused | 1 (6.3) | 2 (12.5) | – | – |
| Missed | 4 (25.0) | 5 (31.3) | – | – |
| Patient died | 1 (6.3) | 0 (0) | – | – |
| Six-minute walk distance (meters) | 117 [0–270], n=11 | 130 [60–242], n=9 | – | >0.99 |
| Baseline SF-36 | n=131 | n=133 | ||
| Physical component score | 46.6±9.4 | 45.2±10.8 | 0 | – |
| Mental component score | 48.6±11.6 | 49.3±10.9 | 0 | – |
| Baseline Barthel Index of ADL | n=136 | n=134 | ||
| Total score | 98.7±7.4 | 99.0±5.9 | 0 | – |
| 30-day SF-36 | n=119 | n=121 | ||
| Physical component score | 39.4±8.2 | 39.6±9.1 | −1.1 (−3.2, 1.0) | 0.29 |
| Mental component score | 49.5±13.4 | 49.9±12.8 | −0.2 (−3.2, 2.8) | 0.91 |
| 30-day Barthel Index of ADL | n=128 | n=124 | ||
| Total score | 94.4±15.0 | 93.5±19.5 | 0.7 (−3.4, 4.7) | 0.76 |
| Three-month SF-36 | n=128 | n=117 | ||
| Physical component score | 46.4±9.8 | 46.1±9.6 | −0.4 (−2.5, 1.8) | 0.74 |
| Mental component score | 51.1±11.1 | 52.1±11.4 | −0.8 (−3.4, 1.8) | 0.54 |
| Three-month Barthel Index of ADL | n=126 | n=126 | ||
| Total score | 98.1±7.9 | 95.9±15.9 | 1.9 (−1.0, 4.8) | 0.20 |
| Six-month SF-36 | n=122 | n=114 | ||
| Physical component score | 49.9±9.3 | 50.0±9.6 | −0.2 (−2.4, 2.1) | 0.89 |
| Mental component score | 51.2±11.5 | 52.6±10.5 | −0.8 (−3.3, 1.7) | 0.52 |
| Six-month Barthel Index of ADL | n=126 | n=120 | ||
| Total score | 98.4±9.9 | 96.7±13.8 | 1.8 (−1.1, 4.6) | 0.23 |
| Employment status | n=113 | n=107 | ||
| Retired or disabled (unchanged from baseline) | 50 (44.2) | 60 (56.1) | – | – |
| Working full time (≥32 h/week) | 30 (26.5) | 24 (22.4) | – | – |
| Working part time | 8 (7.1) | 5 (4.7) | – | – |
| On sick leave but employed | 8 (7.1) | 8 (7.5) | – | – |
| Temporarily laid off | 0 (0.0) | 1 (0.9) | – | – |
| Unemployed, seeking work | 3 (2.7) | 2 (1.9) | – | – |
| Unemployed due to health-related reasons | 3 (2.7) | 2 (1.9) | – | – |
| Homemaker | 3 (2.7) | 2 (1.9) | – | – |
| New retirement (post-discharge) | 1 (0.9) | 0 (0.0) | – | – |
| New or pending disability benefits (post-discharge) | 0 (0.0) | 1 (0.9) | – | – |
| Other | 2 (1.8) | 1 (0.9) | – | – |
| No response | 5 (4.4) | 1 (0.9) | – | – |
Data are presented as n (%), mean ± standard deviation or median [interquartile range]. †, P values were calculated using the Mann-Whitney U test for continuous variables and the Chi-squared test, or Fisher’s exact test when expected cell counts were <5. ADL, activities of daily living; CI, confidence interval; SF-36, 36-Item Short Form Health Survey.