Table 3.
Results of univariable and multivariable logistic regression model in ADNI cohort
| Characteristics | Univariable Logistic Regression | Multivariable Logistic Regression | ||
|---|---|---|---|---|
| OR (95% CI) P | OR (95% CI) P | |||
| Age | 1.01 (0.99–1.03) | 0.24 | 1.03 (1.01–1.06) | 0.02* |
| Gender (male vs. female) | 1.24 (0.93–1.64) | 0.14 | 1.46 (1.03–2.09) | 0.04* |
| Race (vs. Asian) | ||||
| White | 1.20 (0.72–2.03) | 0.50 | 0.37 (0.11–1.30) | 0.11 |
| More than one | 1.28 (0.31–4.86) | 0.72 | 0.35 (0.05–2.39) | 0.28 |
| Black or African American | 0.63 (0.32–1.20) | 0.17 | 0.16 (0.04–0.70) | 0.01* |
| Education | 0.86 (0.81–0.90) | 2.80E-09*** | 0.84 (0.79–0.89) | 1.35E-08*** |
| APOEε4 | 3.98 (3.11–5.14) | 3.36E-27*** | 4.13 (3.18–5.41) | 1.06E-25*** |
| Lipoprotein indicator | ||||
| L-LDL-FC-PCT | 1.19 (1.04–1.38) | 0.014* | 1.20 (1.00–1.43) | 0.047* |
| L-LDL-PL-PCT | 1.37 (1.05–1.79) | 0.022* | 1.23 (0.89–1.70) | 0.22 |
| S-LDL-C-PCT | 1.12 (1.02–1.23) | 0.015* | 1.07 (0.96–1.20) | 0.20 |
Note: p values are presented without correction for multiple comparisons. Significance levels are denoted by asterisks (* p < 0.05, ** p < 0.01, *** p < 0.001). Abbreviations: AD, Alzheimer’s Disease; APOE, apolipoprotein E; CN, cognitively normal; OR, odds ratio; CI, confidence interval; LDL, low-density lipoprotein; L-LDL-FC-PCT, free cholesterol to total lipids ratio in large LDL; L-LDL-PL-PCT, phospholipids to total lipids ratio in large LDL; S-LDL-C-PCT, cholesterol to total lipids ratio in small LDL