Figure 3.

Camptothecin sensitivity of DNA repair mutants in combination with tdp1 and/or rad1. Strains derived from the BY4741 array were assayed for camptothecin sensitivity. Bars represent the mean ± standard deviation of the IC₅₀ of at least two independent isolates. Horizontal lines indicate the IC₅₀ values of wild-type, tdp1 rad1, and rad52 strains for comparison. One mutant series is shown in A–K in the order: mutx, tdp1 mutx, rad1 mutx, tdp1 rad1 mutx (where “mutx ” varies between panels). ND, not determined.