Figure 2.

Structure of LG72 protein and evolution of its putative orthologues in primates. DNA from four different primates (chimpanzee, gorilla, gibbon, and rhesus monkey) were amplified by using specific primers from the human G72 gene. Amplicons were sequenced, and exons were defined by homology to the corresponding human exons. Alignment of theoretical polypeptide sequences corresponding to pLG72 in human and these different primate species is shown. pLG72 translation in chimpanzee and gorilla is altered by a 4-nt insertion causing a frameshift and a premature stop. In rhesus monkey, the insertion of one T at the end of Exon M causes a frameshift and a premature stop.