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. 2026 Feb 25;17:1671502. doi: 10.3389/fimmu.2026.1671502

Figure 2.

Infographic outlining MQC-mediated chondrocyte fate in early osteoarthritis, depicting pathological characteristics, mitochondrial and MQC dysfunctions, and osteoarthritis progression with related therapeutic targets such as pharmacological interventions, gene therapy, cell-based therapy, exercise, and diets.

MQC-mediated chondrocyte fate in early OA: This figure systematically summarizes the core pathophysiological characteristics of chondrocytes during the occurrence and development of osteoarthritis, elaborates on the specific manifestations of mitochondrial dysfunction and the molecular mechanism of MQC disorder, and finally focuses on potential therapeutic targets centered on mitochondrial function regulation and MQC disorder correction, providing a clear mechanistic reference and intervention direction for the precise prevention and treatment of osteoarthritis.