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. 2005 Aug 8;7(6):R1174–R1182. doi: 10.1186/ar1801

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Copyright © 2005 Omoto et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Morphological features and histopathological aspects of the hindlimb in AIA rats. (a) Control rats and (b) rats treated with tetrathiomolybdate (TM). Joint swelling, redness, and edema of the foot in AIA was clearly reduced with TM administration at day 17 after immunization. Histopathological studies using hematoxylin and eosin staining of the foot joint also revealed (c) a marked decrease of synovial inflammatory cell infiltrate and synovial lining hyperplasia compared with (d) control rats. (c), (d) Original magnification × 40. AIA, adjuvant-induced arthritis; MC, monocyte; SL, synovial lining cell; OC, osteoclast.