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. 2005 Aug 8;7(6):R1174–R1182. doi: 10.1186/ar1801

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Copyright © 2005 Omoto et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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VEGF levels in the serum are correlated with the extent of arthritis in rats. (a) VEGF levels in the serum are higher in control rats than in tetrathiomolybdate (TM)-treated rats (* P < 0.01). VEGF was analyzed by ELISA, as described in Materials and methods. Data represent the mean ± standard deviation. (b) A significant positive relationship between VEGF levels in the serum and the severity of pannus formation in hindlimbs of adjuvant-induced arthritis rats, which includes both the control group and the TM-treated group. VEGF, vascular endothelial growth factor.