Table 3.
Association of PTPN22 genotypes carrying the 1858T allele and rheumatoid factor-seropositive (RF+) rheumatoid arthritis (RA)
| PTPN22 genotypes [% (n)] | Pa | Odds ratio (95% confidence interval) | ||||
| C/C | C/T | T/T | C/T or T/T | |||
| TDT RA sample 1 | ||||||
| All TDT RA index cases (n = 100) | 65 (65) | 31 (31) | 4 (4) | 35 (35) | ||
| Controlsb (n = 100) | 79 (79) | 20 (20) | 1 (1) | 21 (21) | 0.029 | 2.05 (1.07–3.81) |
| TDT RA index cases RF+ (n = 81) | 64 (52) | 31 (25) | 5 (4) | 36 (29) | ||
| Controlsb (n = 81) | 79 (64) | 20 (16) | 1 (1) | 21 (17) | 0.038 | 2.1 (1.04–4.24) |
| TDT RA index cases RF- (n = 19) | 68 (13) | 32 (6) | 0 | 32 (6) | ||
| Controlsb (n = 19) | 79 (15) | 21 (4) | 0 | 21 (4) | 0.71 | |
| TDT RA sample 2 | ||||||
| All TDT RA index cases (n = 100) | 69 (69) | 27 (27) | 4 (4) | 31 (31) | 0.76 | |
| Controlsb (n = 100) | 71 (71) | 26 (26) | 3 (3) | 29 (29) | ||
| TDT RA index cases RF+ (n = 76) | 68 (52) | 28 (21) | 4 (3) | 32 (24) | ||
| Controlsb (n = 76) | 74 (56) | 24 (18) | 2 (2) | 26 (20) | 0.47 | |
| TDT RA index cases RF- (n = 24) | 71 (17) | 25 (6) | 4 (1) | 29 (7) | ||
| Controlsb (n = 24) | 63 (15) | 33 (8) | 4 (1) | 37 (9) | 0.76 | |
| All TDT RA families | ||||||
| All TDT RA index cases (n = 200) | 67 (134) | 29 (58) | 4 (8) | 33 (66) | ||
| Controlsb (n = 200) | 75 (150) | 23 (46) | 2 (4) | 25 (50) | 0.078 | |
| TDT RA index cases RF+ (n = 157) | 66 (104) | 29 (46) | 5 (7) | 34 (53) | ||
| Controlsb (n = 157) | 76 (120) | 22 (34) | 2 (3) | 24 (37) | 0.047 | 1.69 (1.03–2.78) |
| TDT RA index cases RF- (n = 43) | 70 (30) | 28 (12) | 2 (1) | 30 (13) | ||
| Controlsb (n = 43) | 70 (30) | 28 (12) | 2 (1) | 30 (13) | 1 | |
RF-, seronegative for rheumatoid factor.
aFollowing data previously reported in RA and because of the infrequency of the PTPN22-1858T/T genotype, it was combined with the 1858C/T genotype for the analysis.
bControls derived from nontransmitted parental chromosomes.