Table 4.

Association between TNF-RII T676G single nucleotide polymorphism genotype and sTNFR levels released by T cells

Genotype	n (%)	sTNF-RI (pg/ml)	sTNF-RII (pg/ml)
Unstimulated T cells
TT	38 (65.5)	166.8 ± 57.8	582.2 ± 259.6
TG	15 (25.9)	144.1 ± 78.2	428.1 ± 222.3
GG	5 (8.6)	137.2 ± 68.9	398.8 ± 194.9
Stimulated T cells
TT	38 (65.5)	178.0 ± 57.9	998.3 ± 355.6
TG	15 (25.9)	146.5 ± 75.5	769.5 ± 292.8
GG	5 (8.6)	141.6 ± 75.7	724.4 ± 167.3

Shown is the association between tumour necrosis factor receptor II (TNF-RII) T676G single nucleotide polymorphism genotype and soluble tumour necrosis factor (sTNFR) levels released by T cells isolated from rheumatoid arthritis (RA) patients (n = 58). sTNFR levels are expressed as mean ± standard deviation. Levels of sTNFR released into culture medium of isolated T cells exhibited a similar trend of decreasing levels of both receptors according to TNF-RII genotype (order: TT > TG > GG), although only the associations with sTNF-RII were significant (unstimulated and stimulated cells, respectively: P for trend = 0.049 and P for trend = 0.02; multiple regression analysis corrected for age, sex and disease duration). sTNF-RI, soluble tumor necrosis factor receptor I.