Figure 2.

Effect of DHMEQ on radiographic findings in collagen-induced arthritis in mice. (a) A representative radiograph of the left metatarsophalangeal (MTP) joints of a mouse treated with dehydroxymethylepoxyquinomicin (DHMEQ), which shows small bone erosions, and (b) that of a control mouse, which shows remarkable soft tissue swelling and large bone erosions. (c) Soft tissue swelling and (d) bone erosions of bilateral second, third and fourth MTP joints observed in the radiographs were scored as described in the Materials and methods section. Values are expressed as the mean ± standard deviation of the total scores of 10 mice in each group, determined by five independent observers.