Figure 3.

Effect of DHMEQ on histopathologic findings in collagen-induced arthritis in mice. (a) A representative specimen of the metatarsophalangeal (MTP) joint of a dehydroxymethylepoxyquinomicin (DHMEQ)-treated mouse, showing almost normal findings, and (b) that of a control mouse showing remarkable cell infiltration in the synovium and bone destruction accompanied by pannus invasion into the marrow space. The severity of (c) synovitis and (d) bone destruction in the specimens were scored as described in the Materials and methods section. Values are expressed as the mean ± standard deviation of the total scores of 10 mice in each group, determined by five independent observers.