Table 1.
Dipeptidyl peptidase IV/CD26 in rheumatoid arthritis
| Peripheral blood CD3+CD26+ | Peripheral blood CD4+CD26+ | Synovial fluid CD3+CD26+ | Serum/plasma DPPIV activity (μmol/min/l) | Synovial DPPIV activity (μmol/min/l) | Notes | Reference | |
| Controls | 12.9 ± 4.7 | Ta1 antibody; all active with therapy | [47] | ||||
| RA (active) | 40.2 ± 10.6 | Ta1 antibody; all active with therapy | [47] | ||||
| Controls | 58.2 ± 10.6 | 1F7 antibody; all active with therapy | [47] | ||||
| RA (active) | 72.0 ± 8.8 | 1F7 antibody; all active with therapy | [47] | ||||
| Controls | 12.3 ± 4.2 | Ta1 antibody | [49] | ||||
| OA | 8.1 ± 2.0 | Ta1 antibody | [49] | ||||
| RA (inactive) | 41.6 ± 23.1 | Ta1 antibody | [49] | ||||
| RA (active) | 62.2 ± 10.1 | Ta1 antibody | [49] | ||||
| Controls | 58.8 ± 9.0 | 1F7 antibody | [123] | ||||
| OA | 49.0 ± 11.0 | 1F7 antibody | [123] | ||||
| RA (inactive) | 60.6 ± 4.0 | 1F7 antibody | [123] | ||||
| RA (active) | 75.9 ± 10.0 | 36.3 ± 10.0 | 1F7 antibody | [123] | |||
| OA | 36.7 ± 6.5 (CD26: 614 ± 157 ng/ml) | 14.6 ± 4.4 (CD26: 247 ± 25 ng/ml) | [55] | ||||
| RA | [55] | ||||||
| All | 26.7 ± 9.9 (CD26: 473 ± 176 ng/ml) | 16.1 ± 5.6 (CD26: 259 ± 80 ng/ml) | [55] | ||||
| Non-inflammatory | 31.8 ± 12.7 (CD26: 558 ± 195 ng/ml) | (n = 24; CRP < 20 mg/l) | [55] | ||||
| Inflammatory | 22.4 ± 4.7 (CD26: 404 ± 139 ng/ml) | (n = 17; CRP > 20 mg/l) | [55] | ||||
| Controls | 41.3 ± 4.7 | [32] | |||||
| RA (active) | 34.5 ± 3.2 | [32] | |||||
| SLE | 29.9 ± 6.5 | [32] | |||||
| OA | 702.6 ± 41.2 mU/mg | Synovial fluid | [60] | ||||
| RA (active) | 549.6 ± 28.3 mU/mg | Synovial fluid | [60] | ||||
| Controls | 634 μmol/min/mol | [36] | |||||
| Sjogren's syndrome | 969 μmol/min/mol | [36] | |||||
| SLE | 650 μmol/min/mol | [36] | |||||
| RA (active) | 224 μmol/min/mol | [36] | |||||
| OA | 1.0 ± 1.4 nmol/min/mg | Synovial membranes | [54] | ||||
| RA (active) | |||||||
| All grades | 1.1 ± 1.1 nmol/min/mg | Synovial membranes | [54] | ||||
| Grade 1 (0–10 ml fluid) | 1.8 ± 1.4 nmol/min/mg | Synovial membranes | [54] | ||||
| Grade 2 (10–20 ml fluid) | 0.9 ± 0.6 nmol/min/mg | Synovial membranes | [54] | ||||
| Grade 3 (> 20 ml fluid) | 0.6 ± 0.5 nmol/min/mg | Synovial membranes | [54] |
CRP, C-reactive protein; DPP, dipeptidyl peptidase; OA, osteoarthritis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus. Values for peripheral blood CD3+CD26+, peripheral blood CD4+CD26+ and synovial fluid CD3+CD26+ are shown as % gated lymphocytes.