Table 1.
Baseline characteristics of the patients
| Characteristic | rhAPC group (n = 12) | Control group (n = 12) |
| Age, years | 57 ± 16 | 66 ± 14 |
| Male sex (%) | 7 (58) | 7 (58) |
| Pre-existing conditions, n | 7 | 16 |
| Malignancy | 2 | 7 |
| Diabetes | 1 | 3 |
| Hypertension | 2 | 2 |
| COPD | 1 | 2 |
| Myocardial infarction | 0 | 1 |
| Pancreatitis | 1 | 1 |
| Recent surgery (%) | 3 (25) | 3 (25) |
| APACHE II score | 21 ± 6 | 22 ± 6 |
| Mechanical ventilation | 12 | 11 |
| Shock | 12 | 12 |
| Vasopressor use | 11 | 11 |
| Renal replacement therapy | 4 | 4 |
| Number of dysfunctional organ systems | 4 ± 1 | 3 ± 1 |
| SOFA score at inclusion | 10 ± 3 | 9 ± 2 |
| Site of infection, n | ||
| Lung | 8 | 8 |
| Urinary tract | 2 | 0 |
| Other | 2 | 4 |
| Causes of infection, n | ||
| Gram positive | 6 | 4 |
| Gram negative | 7 | 5 |
| Anaerobes | 0 | 1 |
| Fungi | 1 | 2 |
Data represent mean ± SD. APACHE, Acute Physiology and Chronic Health Evaluation; COPD, chronic obstructive pulmonary disease; SOFA, sepsis-related organ failure assessment.