Table 1.
Acid | Patient group | |||||||||||||
Diabetic ketoacidosis | Lactic acidosis | Unknown origin | Normal anion gap | Controls | ||||||||||
Mean | SD | p | Mean | SD | p | Mean | SD | p | Mean | SD | p | Mean | SD | |
Citrate | 454.02 | 194.11 | ns | 1,453.13 | 513.95 | <0.01 | 335.63 | 69.82 | nsa | 239.1 | 105.1 | ns | 448.55 | 119.80 |
Isocitrate | 421.93 | 352.56 | 0.02 | 704.6 | 347.6 | <0.01 | 949.16 | 883.22 | <0.01a | 84.48 | 69.6 | nsa | 60.97 | 31.31 |
α-Ketoglutarate | 413.41 | 158.48 | <0.01a | 547.72 | 344.98 | <0.01a | 651.51 | 203.06 | <0.01a | 72.97 | 67.34 | nsa | 79.17 | 106.74 |
Succinate | 181.1 | 173.24 | ns | 358.27 | 112.49 | <0.01a | 340.04 | 128.74 | 0.02a | 125.89 | 73.57 | nsa | 90.29 | 49.97 |
Malate | 229.81 | 181.87 | <0.01a | 593.65 | 265.88 | <0.01 | 485.16 | 189.67 | <0.01a | 95.07 | 117.59 | ns | 59.82 | 32.94 |
d-Lactate | 157.34 | 67.85 | <0.01 | 397.69 | 511.15 | <0.01a | 176.49 | 135.21 | <0.01 | 69.27 | 55.39 | <0.01 | 35.63 | 18.42 |
For each group, statistical analysis is presented relative to control value. aMann-Whitney non-parametric test. ns, not significant; SD, standard deviation.