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Diminished resorption does not enhance osteoclastogenesis in TRPV5-/- mice. Murine bone marrow cells from TRPV5+/+ and TRPV5-/- mice were cultured on plastic instead of cortical bone slices for 6 days and stained for TRACP. The amount of osteoclasts (A) and the number of nuclei per osteoclast (B) was measured for both cultures (n = 6). Values are presented as mean ± SEM. *, P < 0.05 versus TRPV5+/+ cultures.
