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. 2005 Nov 27;33(21):6694–6699. doi: 10.1093/nar/gki981

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Binding of mRNA to eIF4E and eIF4E complexed to an eIF4G fragment. (A) Temperature-dependence of binding differential (ΔG_4E/4G→4E, ΔH_4E/4G→4E, −TΔS_4E/4G→4E), with more favourable binding to eIF4E/4G complex denoted by positive ΔG values. Results (ΔG) are shown for variable polymer length. (B) RNA monomer densities (green) around eIF4E and eIF4E/4G complexes, with electrostatic potential surfaces at −k_BT/e (red) and k_BT/e (blue). The ribbon diagram is colour-coded according to eIF4E (cyan) and eIF4G fragment (orange), with a spacefilled cap analogue in all panels. This figure was drawn with Swiss PDB-Viewer (46).