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Physiological characterization of S4-S5 loop mutants. (A) Both mutant and wild-type channels generate large currents upon depolarization, with similar activation kinetics. (B) Current-voltage relation for KCNQ2_T217A/KCNQ3_T246A, KCNQ2_T217D/KCNQ3_T246D, wild-type KCNQ, and endogenous channels. KCNQ2_T217D/KCNQ3_T246D channels are nonfunctional. Results shown are representative of more than five batches of oocytes, with n ≥ 5 oocytes per condition per batch. Error bars represent SEM.
