Table 4.
Stratified analysis of the association between continuous MCMI and incident chronic diseases
| Disease | Subgroup | Level | HR (95% CI) | P-value | P for interaction |
|---|---|---|---|---|---|
| Hypertension | Age group | < 60 | 1.10 (1.06–1.15) | < 0.001 | 0.047 |
| ≥ 60 | 1.24 (1.13–1.35) | < 0.001 | |||
| Gender | Male | 1.38 (1.23–1.54) | < 0.001 | < 0.001 | |
| Female | 1.10 (1.05–1.14) | < 0.001 | |||
| Smoking status | Yes | 1.26 (1.15–1.38) | < 0.001 | 0.008 | |
| No | 1.10 (1.06–1.14) | < 0.001 | |||
| Drinking status | Yes | 1.34 (1.20–1.50) | < 0.001 | 0.001 | |
| No | 1.10 (1.06–1.14) | < 0.001 | |||
| Diabetes | Age group | < 60 | 1.13 (1.09–1.17) | < 0.001 | < 0.001 |
| ≥ 60 | 1.37 (1.26–1.48) | < 0.001 | |||
| Gender | Male | 1.43 (1.32–1.56) | < 0.001 | < 0.001 | |
| Female | 1.13 (1.09–1.17) | < 0.001 | |||
| Smoking status | Yes | 1.42 (1.31–1.53) | < 0.001 | < 0.001 | |
| No | 1.12 (1.08–1.16) | < 0.001 | |||
| Drinking status | Yes | 1.43 (1.31–1.55) | < 0.001 | < 0.001 | |
| No | 1.13 (1.09–1.17) | < 0.001 | |||
| Cancer | Age group | < 60 | 1.08 (0.95–1.22) | 0.249 | 0.899 |
| ≥ 60 | 1.13 (0.86–1.49) | 0.368 | |||
| Gender | Male | 1.16 (0.85–1.58) | 0.363 | 0.999 | |
| Female | 1.08 (0.96–1.22) | 0.203 | |||
| Smoking status | Yes | 1.11 (0.82–1.52) | 0.493 | 0.987 | |
| No | 1.09 (0.97–1.23) | 0.154 | |||
| Drinking status | Yes | 1.27 (0.98–1.64) | 0.074 | 0.446 | |
| No | 1.06 (0.91–1.23) | 0.463 | |||
| Lung Disease | Age group | < 60 | 1.07 (0.93–1.22) | 0.342 | 0.010 |
| ≥ 60 | 0.88 (0.77–1.01) | 0.066 | |||
| Gender | Male | 0.88 (0.77–1.02) | 0.080 | 0.119 | |
| Female | 1.05 (0.93–1.19) | 0.451 | |||
| Smoking status | Yes | 0.90 (0.78–1.04) | 0.145 | 0.354 | |
| No | 1.02 (0.90–1.16) | 0.755 | |||
| Drinking status | Yes | 0.87 (0.76–1.01) | 0.072 | 0.142 | |
| No | 1.04 (0.92–1.18) | 0.520 | |||
| Heart Disease | Age group | < 60 | 1.11 (1.05–1.17) | < 0.001 | 0.066 |
| ≥ 60 | 1.03 (0.92–1.16) | 0.591 | |||
| Gender | Male | 1.12 (0.99–1.26) | 0.070 | 0.551 | |
| Female | 1.09 (1.02–1.16) | 0.011 | |||
| Smoking status | Yes | 1.07 (0.94–1.21) | 0.307 | 0.758 | |
| No | 1.10 (1.04–1.17) | 0.002 | |||
| Drinking status | Yes | 1.05 (0.92–1.21) | 0.467 | 0.502 | |
| No | 1.10 (1.04–1.16) | < 0.001 | |||
| Stroke | Age group | < 60 | 1.10 (1.03–1.18) | 0.005 | 0.440 |
| ≥ 60 | 1.21 (1.09–1.36) | < 0.001 | |||
| Gender | Male | 1.25 (1.12–1.39) | < 0.001 | 0.063 | |
| Female | 1.10 (1.02–1.18) | 0.010 | |||
| Smoking status | Yes | 1.24 (1.11–1.39) | < 0.001 | 0.162 | |
| No | 1.10 (1.03–1.18) | 0.004 | |||
| Drinking status | Yes | 1.18 (1.03–1.35) | 0.019 | 0.485 | |
| No | 1.11 (1.05–1.18) | < 0.001 | |||
| Psychological Problem | Age group | < 60 | 0.80 (0.61–1.04) | 0.094 | 0.678 |
| ≥ 60 | 0.91 (0.69–1.22) | 0.536 | |||
| Gender | Male | 1.01 (0.74–1.39) | 0.932 | 0.272 | |
| Female | 0.78 (0.62–0.99) | 0.041 | |||
| Smoking status | Yes | 0.97 (0.68–1.38) | 0.860 | 0.304 | |
| No | 0.81 (0.65–1.01) | 0.066 | |||
| Drinking status | Yes | 0.75 (0.53–1.07) | 0.117 | 0.641 | |
| No | 0.89 (0.71–1.12) | 0.328 | |||
| Arthritis | Age group | < 60 | 1.00 (0.92–1.08) | 0.949 | 0.620 |
| ≥ 60 | 0.96 (0.85–1.07) | 0.428 | |||
| Gender | Male | 0.98 (0.87–1.11) | 0.779 | 0.642 | |
| Female | 0.98 (0.91–1.07) | 0.698 | |||
| Smoking status | Yes | 1.01 (0.90–1.14) | 0.859 | 0.607 | |
| No | 0.97 (0.90–1.06) | 0.538 | |||
| Drinking status | Yes | 1.02 (0.90–1.16) | 0.757 | 0.441 | |
| No | 0.97 (0.89–1.05) | 0.437 | |||
| Dyslipidemia | Age group | < 60 | 1.10 (1.07–1.13) | < 0.001 | 0.037 |
| ≥ 60 | 1.22 (1.14–1.31) | < 0.001 | |||
| Gender | Male | 1.32 (1.24–1.42) | < 0.001 | < 0.001 | |
| Female | 1.09 (1.05–1.12) | < 0.001 | |||
| Smoking status | Yes | 1.28 (1.20–1.37) | < 0.001 | < 0.001 | |
| No | 1.09 (1.06–1.13) | < 0.001 | |||
| Drinking status | Yes | 1.31 (1.22–1.41) | < 0.001 | < 0.001 | |
| No | 1.09 (1.06–1.13) | < 0.001 | |||
| Liver Disease | Age group | < 60 | 1.05 (0.96–1.15) | 0.251 | 0.956 |
| ≥ 60 | 1.09 (0.92–1.28) | 0.311 | |||
| Gender | Male | 1.13 (0.97–1.32) | 0.109 | 0.270 | |
| Female | 1.04 (0.93–1.16) | 0.497 | |||
| Smoking status | Yes | 1.14 (0.98–1.32) | 0.086 | 0.291 | |
| No | 1.03 (0.92–1.15) | 0.606 | |||
| Drinking status | Yes | 1.12 (0.95–1.32) | 0.195 | 0.633 | |
| No | 1.04 (0.94–1.15) | 0.450 | |||
| Kidney Disease | Age group | < 60 | 0.99 (0.86–1.13) | 0.848 | 0.819 |
| ≥ 60 | 0.98 (0.85–1.15) | 0.843 | |||
| Gender | Male | 0.93 (0.79–1.09) | 0.352 | 0.395 | |
| Female | 1.02 (0.91–1.13) | 0.768 | |||
| Smoking status | Yes | 1.06 (0.91–1.23) | 0.455 | 0.204 | |
| No | 0.93 (0.81–1.08) | 0.336 | |||
| Drinking status | Yes | 1.03 (0.87–1.22) | 0.708 | 0.620 | |
| No | 0.94 (0.82–1.09) | 0.417 | |||
| Digestive Disease | Age group | < 60 | 0.95 (0.85–1.05) | 0.301 | 0.084 |
| ≥ 60 | 0.83 (0.73–0.95) | 0.006 | |||
| Gender | Male | 0.80 (0.69–0.92) | 0.002 | 0.054 | |
| Female | 0.96 (0.87–1.05) | 0.369 | |||
| Smoking status | Yes | 0.81 (0.70–0.94) | 0.005 | 0.211 | |
| No | 0.95 (0.86–1.05) | 0.314 | |||
| Drinking status | Yes | 0.79 (0.69–0.92) | 0.002 | 0.073 | |
| No | 0.95 (0.86–1.05) | 0.321 | |||
| Asthma | Age group | < 60 | 1.03 (0.80–1.33) | 0.806 | 0.412 |
| ≥ 60 | 0.91 (0.74–1.13) | 0.400 | |||
| Gender | Male | 0.89 (0.70–1.13) | 0.339 | 0.351 | |
| Female | 1.03 (0.83–1.28) | 0.791 | |||
| Smoking status | Yes | 0.90 (0.71–1.14) | 0.369 | 0.434 | |
| No | 1.03 (0.82–1.29) | 0.784 | |||
| Drinking status | Yes | 0.79 (0.61–1.02) | 0.075 | 0.049 | |
| No | 1.11 (0.91–1.36) | 0.282 |
All hazard ratios were adjusted for age, gender, education, marital status, residence, smoking, drinking, physical activity (METs), C-reactive protein (CRP), ADL disability, self-reported health, and chronic disease count at baseline, except for the stratification variable itself. P for interaction was derived from the coefficient of the cross-product term between the continuous MCMI and the dichotomized subgroup variable
ADL, Activities of Daily Living; CI, Confidence Interval; HR, Hazard Ratio; MET, Metabolic Equivalent of Task